Acting Through the Ages Essay Essays

Acting Through the Ages Essay Essays Acting Through the Ages Essay Paper Acting Through the Ages Essay Paper The art of playing has evolved in many ways over its life-time and continues to germinate to this twenty-four hours. Acting foremost originated in Greece in the sixth century BC with the Grecian tragic histrion Thespis being widely regarded as the laminitis of the profession. This is why. to this twenty-four hours. histrions are frequently referred to as actors. Aristotle. the Grecian philosopher. defined moving as ‘the right direction of the voice to show assorted emotions ‘ and declared it to be a natural endowment that was unconditioned and could non be taught. There are a few antediluvian Greek dramas by Aeschylus. Euripides and Sophocles that survived all moving history and are still performed in the theaters. During the Christian regulation of Rome. moving began to worsen as an art and liturgical play began to be performed throughout the Middle Ages. The tradition was kept alive by jugglers. acrobats and mummers who entertained crowds at town carnivals and the gesture and modulation of histrions began to be mastered through spiritual play performed in church. Acting history so takes an tremendous leap to the sixteenth century. where modern professional playing began to emerge through Italian comedy. William Shakespeare is possibly the most adept of this peculiar manner of dramatist – and surely the best known. Many professional histrions during the Restoration period were famed for their natural endowment and manner but it was non until the eighteenth century that moving was considered a serious profession instead than an inexpert chase. In the mid-18th century. Charles Macklin and his student David Garrick began to present a new. realistic. manner of moving and new motions began to take topographic point across Europe. As moving history evolves. the old. declamatory. manner of moving did non decease out wholly until the beginning of the twentieth century with many popular histrions of this clip looking excessively melodramatic to many modern audiences. With the altering times. gustatory sensations and civilizations came a move off from the declamatory and intense moving manners of past ( with criterions set by the Meiningen Players in 1874 ) and the outgrowth of a new. realistic manner of moving whereby the histrion strives for absolute psychological designation with the character he is playing – the Stanislavski method introduced by Russian manager Konstantin Stanislavski. This method was adopted by the Group Theatre and subsequently by Lee Strasberg bring forthing a coevals of gifted realistic histrions such as Marlon Brando. The debut of gesture image and telecasting amusement began to offer a wealth of chances and associated stardom to draw a bead oning histrions and actresses and began to alter the art of moving forever. In the early twentieth century. the Academy Awards were launched and the profession of moving eventually began to be decently recognised as an admirable and reliable professional chase.

sexual consequences in adolesc essays

sexual consequences in adolesc essays Sexual activity hurts adolescents. Sadly, large numbers of children are placing themselves at risk by engaging in sexual activity early in their lives. Health risks are not the only consequences however. Sexually promiscuous lifestyles bring with them heavy responsibilities and commitments that young people cannot handle. Young adolescents do not have the capacity and maturing to endure the social, emotional, and psychological responsibilities that accompany their sexual choices. Sadly, the consequences include unwanted pregnancies, sexually transmitted diseases, and broken relationships, to name a few. The purpose of this essay is to investigate and discuss some of the research surrounding early sexual activity in adolescents. We will examine the findings of several academic journals, identify some of the current trends in sexual activity in adolescence, and examine the implications that follow. Lets begin by looking at some statistics regarding sexual promiscuity in adolescents. The statistics are frightening. According to the Alan Guttmacher Institute, about 80% of teenagers engage in sex by age 19 and most experience intercourse an average of 8 years before marriage. Roughly 1-in-4 sexually active teens acquires a sexually transmitted disease by age 20. Ten percent of all women become pregnant by their late teens, 78% of which are unwanted. For every ten teen pregnancies, four will be aborted. Of all rape victims, one in every two is a teenager. (Guttmacher, 1999). These statistics are overwhelming and frightening. Next, we will discuss 3 research articles that engage the teenage sexual crisis. Lets examine an article by Shaughnessy and Shakesby (1992). The authors were interested in the effects of sexual activity on the emotional and social development of adolescents. Their article comes from an academic journal entitled, Adolescence, Vol. 27, Issue 106. The conclusion drawn from their research in...

Who Benefits In Recession Essay Example | Topics and Well Written Essays - 3750 words

Who Benefits In Recession - Essay Example That would take care of the other factors in the economy and that would help to define the recession. (Brainard & Perry, 2001, Pp. 176-177). The recession has a severe effect on the economy as seen by the events during the recession. As the GDP decreases the country attracts less investment. There is a dearth of investment during the recession. There is decreased demand in the economy and the companies find it hard to make a commendable business. As a result, there is stock of unused goods and machinery. The consumption function of the economy decreases and this has a multiplier effect in the economy. As there is not a proper utilization of resources, there is a relatively higher production costs. As the production costs are high, therefore, it has an effect on the consumption. Though there is a rise in the production costs, the change in the wages is not uniform. In some cases the workers are thrown out of their jobs and the in the other5 cases there is a decrease in the wages of th e labor. In the case of the productivity, the volume of the production decreases. Therefore, the production of the companies decrease and the companies are on the verge of the extinction. From the typical recession scenario seen from the history of the world, it has been noted that the conditions of the economy needs some time to change. The economic conditions of the country are severe and the companies get closed. This effects the employment in the economy and the production. Most of the employees loose their jobs and experience a pay cut. This makes it hard for the survival of the people in the economy. The conditions are improved in the economy by the intervention strategies of the Government. The condition of the economy during the recession needs some thoughts put in by the Government and the economy needs financial support. In the modern world, most of the countries have minimum intervention strategies by the Government. But during the

Anorexia Nervosa in Today's Society Essay Example | Topics and Well Written Essays - 2250 words

Anorexia Nervosa in Today's Society - Essay Example Although Anorexia Nervosa mostly affects female population aged 15 - 30, girls under 15 and women above 30 can suffer from this disorder as well. Thus, the oldest patient reported was a woman of 68 without any prior history of eating disorders (Dally, 1984). Anorexia affects certain share of male population: estimated 10 to 15 percent of people with anorexia are men. The highest occurrence of anorexia among males is reported in the age group of young adolescents from 7 to 14 years: nearly 25 percent of anorexia cases in this age group are boys (Herman-Giddens et al, 1997). Experts identify two types of Anorexia Nervosa: food restricting type, and binge eating (purging). The most common characteristic of the restricting type is substantial reduction in calories intake (normally to 300 to 700 kcal per day) and intensive physical over-exercising. By contrast, in the binging type intake of calories may be either small or as high as several thousand followed by purging - self-induced or pharmacologically conditioned vomiting (Yager & Andersen, 2005: 1481). Health complications resulting from either type of this eating disorder affect practically all biological systems of human organism. Anorexia Nervosa poses a number of threats in terms of mental and physiological health. Similarly to other eating disorders Anorexia Nervosa frequently co-occur with depression, substance abuse and anxiety disorders (APAWGED, 2000). Physiologically Anorexia Nervosa causes a wide range of health complications some of which - cardiovascular conditions and kidney failure - are life threatening. However, despite the awareness of the risks associated with anorexia, it is on the rise these days, and a number of laymen and experts even believe that anorexia has already become a norm in modern society. A brief inquiry into the etiology of this eating disorder reveals the reasons for such seemingly strange point of view. MAIN DISCUSSION The cause of Anorexia Nervosa isn't fully understood at present. Possible causes of this eating disorder are: destructive influence of family and society, genetic (inherited) factors, brain dysfunction, neurotransmitter levels imbalances, etc. Yet, none of these factors has been proved to be the key determinant of developing Anorexia as well as no specific life experiences are linked to onset of this eating disorder. Several recent twin studies suggest that Anorexia Nervosa is more than other eating disorders associated with a genetic predisposition (Paris, 1999). Many recent studies associate the risk of developing Anorexia Nervosa with media influence. Evidences and arguments provided by these studies deserve particular attention: media influence may be one of the central factors in extremely high incidence of Anorexia Nervosa among female adolescents. Absolute majority of anorexia nervosa incidents occur in female population: according to estimations of American Psychiatric Association

What Are the Purposes of Prisons Essay Example for Free

What Are the Purposes of Prisons Essay

The Acid Rain Issue Essay -- essays research papers fc

Acid Rain is a serious problem with disastrous effects. Every day this problem increases. Many believe that this issue is too small to deal with, but if the acid rain problem is not met with head on, the effects on people, plants, animals, and the economy will only worsen. In the following paragraphs you will learn what acid rain is, the effects it has on human life, animals, the economy, the economic costs, and what is being done to help to stop this problem. This topic is very important because acid rain effects everyone everywhere all over the world.I. What is acid rain?Acid rain is the combination of two chemicals released into the atmosphere. These chemicals are sulphur dioxide (SO2) and nitrogen oxides (Nox). Natural sources such as volcanoes, sea spray, rotting vegetation and plankton are all contributors to acid rain, but burning fossil fuels, such as coal and oil which are referred to as dry emissions are largely to blame for more than half of the emissions into the world. 2 Nationally, one hundred and twenty tons of sulfur dioxide and nitrogen dioxide are emitted into the air each day.4A. How is acid rain formed?When the sulfur dioxide reaches the atmosphere, it oxidizes to first form a sulfate ion. It then becomes sulfuric acid when it joins with hydrogen atoms in the air and falls back down to earth, usually in the form of rain, snow, or fog. 1 Oxidation occurs the most in clouds and heavily polluted air where other compounds such as ammonia and ozone help to catalyze the reaction, converting more sulphur dioxide to sulphuric acid. The following are the stoichiometric equations for the formation of sulphuric acid:S (in coal) + O2 ? SO22 SO2 + O2 ? 2 SO3SO3 + H2O ? H2SO4Nitric oxide and nitric dioxide are also components of acid rain. Its sources are mainly from power stations and exhaust fumes. Like sulphur dioxide, these nitrogen dioxides also rise into the air and are oxidized in the clouds to form nitric acid. Through this diagram you can better understand how acid rain is formed and emitted into the earth:II. Effects of acid rainAcid rain causes problems in almost every aspect of the environment. Acid rain can have a devastating effect on aquatic life, crops, forests, buildings, and also human life. A. The human environmentAcid rain has a multiplicity of effects in the human environment. The corrosion of limestone buildings in towns ... ... Pennsylvania. These and thousands of other organizations strive to educate the community about the acid rain problem and would be more than happy to send you information about what you can do to help. BibliographyLeslie R. Alm, "Scientists and the Acid Rain policy in Canada and the US." Science, Technology, and Human Values, 1997, 349"Acid Rain: Bad News About The Good News" Business Week, 25 October 1999, 95Anne E. Smith, Jeremy Platt, A. Denny Ellerman, "The cost of reducing SO2: It’s (higher than you think)" Public Utilities Fortnightly, 15 May 1998, 22"Acid Rain-A Definition" <a href="http://www.qlink.queensu.ca">http://www.qlink.queensu.ca"Whats being done? What is Europe and the UN-ECE doing?" <a href="http://www.ec.gc.ca/acidrain">http://www.ec.gc.ca/acidrain"Acid Rain: The Facts" <a href="http://www.brixworth.demon.co.uk">http://www.brixworth.demon.co.ukDepartment od Enviormental Protection, "Acid Rain In Pennsylvania" <a href="http://www.dep.state.pa.us">http://www.dep.state.pa.usChuck, "Acid Rain" ChuckIII’s College Resources

Reflection paper on date rape for Human Sexuality Essay

There are many sad stories of girls who have been violated by someone that they know. They almost all begin with a wonderful night and eventually get taken advantage of. The woman in the situation may feel as though she asked for it. The male may feel as though she didn’t say no, so if I do this I am doing nothing wrong. It is horrifying to me how many times this has happened to a woman. The number of times it happens to women is the most significant thing about date rape to me, because I didn’t realize that it happened so much. I think knowing this will help me to watch out for things around me a little better and make my trust level go down even further. I think all women need to watch out for themselves in sketchy situations. If she or I feel uncomfortable then she or I should try to avoid the situation before it is too late, if possible. This isn’t always as easy as it sounds though. There have been quite a few times that I was in situations where potentially very bad things could have happened to me and out of pure luck they didn’t. I am usually a very trusting person, but the past couple of years I’ve been having to rethink that and become more of an untrusting person to try to protect myself. Men take their strong, masculine image and use it to their advantage. They may try to use guilt, lies, alcohol, and/or aggressiveness to get a girl to have sex with them. If she declines and he still continues to have sex with her, then he is committing a crime. The worst part is that girls don’t really know who to trust or not to trust. It’s a very scary world in which we live. I wish the world was different and it was ok to trust everyone especially the people you are close to, but since it’s not I have to be really careful when choosing who I will trust.

Medical Immunology

MEDICAL IMMUNOLOGY & SEROLOGY Terence L. Eday, RMT, MT(ASCPi), MPH College of Medical Technology / Medical Laboratory Science University of Perpetual Help System DALTA Historical Perspective †¢ 1773, Voltaire reported on an ancient Chinese custom where dried and powdered small pox scabs were inhaled †¢ 1798, Edward Anthony Jenner, Smallpox vaccination †¢ 1862, Ernst Haekel, Recognition of phagocytosis 1877, Paul Erlich, recognition of mast cells Historical Perspective †¢ 1879, Louis Pasteur, Attennuated chicken cholera vaccine development †¢ 1883, Ellie Metchnikoff developed the cellular theory of immunity through phagocytosis; phagocytic theory; cellular theory of vaccination †¢ 1885, Pasteur discovered therapeutic vaccination; first report of live â€Å"attenuated† vaccine for rabies Historical Perspective 1888, Pierre Roux & Alexander Yersin, Bacterial toxins (Yersinia pestis) †¢ 1888, George Nuttall, Bactericidal action of blood †¢ 1 890, Emil von Behring and Kitasata introduced passive immunization into modern medicine; humoral theory of immunity †¢ 1891, Robert Koch demonstrated the cutaneous (delayed-type) hypersensitivity †¢ 1894, Richard Pfeiffer, Bacteriolysis Historical Perspective (1 of 6 ) 1895, Jules Bordet, Complement and antibody activity in bacteriolysis †¢ 1900, Paul Ehrlich, responsible for the antibody formation theory †¢ 1901, Karl Landsteiner, A, B, and O †¢ 1901-8, Carl Jensen & Leo Loeb, Transplantable tumors †¢ 1902, Paul Portier & Charles Richet, Anaphylaxis Historical Perspective (1 of 6 ) †¢ 1903, Nicolas Maurice Arthus, discovered the Arthus reaction of intermediate hypersensitivity †¢ 1903, Almroth Wright and Stewart Douglas observed the humoral component, opsonin †¢ 1906, Clemens von Pirquet, coined the word allergy †¢ 1907, Svante Arrhenius, coined the term immunochemistryHistorical Perspective †¢ 1910, Emil von Dungern, & Ludwik Hirszfeld, Inheritance of ABO blood groups †¢ 1910, Peyton Rous, Viral immunology theory †¢ 1914, Clarence Little, Genetics theory of tumor transplantation †¢ 1915-20, Leonll Strong & Clarence Little, Inbred mouse strains Historical Perspective †¢ 1917, Karl Landsteiner, Haptens †¢ 1921, Carl Prausnitz & Heinz Kustner, Cutaneous reactions †¢ 1924, L. Aschoff, Reticuloendothelial system †¢ 1926, Loyd Felton & GH Bailey, Isolation of pure antibody preparation †¢ 1938, John Marrack, Antigen-antibody binding hypothesis Historical Perspective 1936, Peter Gorer, Identification of the H2 antigen in mice †¢ 1940, Karl Landsteiner & Alexander Weiner, Identification of the Rh Antigens †¢ 1941, Albert Coons, Immunofluorescence technique †¢ 1942, Jules Freund & Katherine McDermott, Adjuvants †¢ 1942, Karl Landsteiner & Merill Chase, Cellular transfer of sensitivity in guinea pigs (anaphylaxis) Historical Perspective †¢ 1944, Peter Medwar, Immunological hypothesis of allograft rejection †¢ 1948, Astrid Fagraeus, Demonstration of antibody production in plasma B cells †¢ 1948, George Snell, Congenic mouse lines †¢ 1949, Macfarlane Burnet & Frank Fenner, Immunological tolerance hypothesisHistorical Perspective †¢ 1950, Richard Gershon and K Kondo, Discovery of supressor T cells †¢ 1952, Ogden and Bruton, discovery of agammaglobulinemia (antibody immunodeficiency) †¢ 1953, Morton Simonsen and WJ Dempster, Graft-versus-host reaction †¢ 1953, James Riley & Geoffrey West, Discovery of histamine in mast cells Historical Perspective †¢ 1953, Rupert Billingham, Leslie Brent, Peter Medwar, & Milan Hasek, Immunological tolerance hypothesis †¢ 1955-1959, Niels Jerne, David Talmage, Macfarlane Burnet, Clonal Selection Theory †¢ 1957, Ernest Witebsky et all. Induction of autoimmunity in animals †¢ 1957, Alik Isaacs & Jean Lindemann, Discovery of interferon (cytokine) Hi storical Perspective †¢ 1958-62, Jean Dausset et al. , Human leukocyte antigens †¢ 1959-62, Rodney Porter et al. , Discovery of antibody structure †¢ 1959, James Gowans, Lympocyte circulation †¢ 1961-62, Jaques Miller et al. , Discovery of thymus involvement in cellular immunity †¢ 1961-62, Noel Warner et al. , Disctinction of cellular and humoral immune response Historical Perspective †¢ 1963, Jacques Oudin et al. Antibody isotypes †¢ 1964-68, Anthony Davis et al. , T and B cell cooperation in immune response †¢ 1965, Thomas Tomasi et al. , Secretory immunoglobulin antibodies †¢ 1967, Kimishige Ishizaka et al. , Identification of IgE as the reaginic antibody Historical Perspective †¢ 1971, Donald Bailey, Recombinant inbred mouse strains †¢ 1972, Gerald M. Edelman & Rodney Porter, Identification of antibody molecule †¢ 1974, Rolf Zinkernagel & Peter Doherty, MHC restriction †¢ 1975, Kohler and Milstein, First monoclona l antibodies used in genetic analysisHistorical Perspective †¢ 1984, Robert Good, Failed treatment of severe combined immunodeficiency (SCID, David the bubble boy) by bone marrow grafting †¢ 1985, Tonegawa, Hood et al. , Identification of immunoglobulin genes †¢ 1985-1987, Leroy Hood et al. , Identification of genes for the T cell receptor †¢ 1986, Monoclonal hepatitis B vaccine Historical Perspective †¢ 1986, Mosmann, Th1 versus Th2 model of T-helper-cell function †¢ 1990, Yamamoto et al. Molecular differences between the genes for blood groups O and A and between those for A and B †¢ 1990, NIH team, Gene therapy for SCID using cultured T cells †¢ 1993, NIH team, Treatment of SCID using genetically altered umbilical cord cells Historical Perspective †¢ 1996-1998, Identification of toll-like receptors †¢ 2001, FOXP3, the gene directing regulatory-T-cell development †¢ 2005, Frazer, Development of human papilloma-virus vaccine Th e IMMUNE SYTEM What is Immunology? †¢ Study of the molecules, cells, organs, and systems responsible for the recognition and disposal of foreign (nonself) material †¢ †¦ ow body components respond and interact †¢ †¦desirable and undesirable consequences of immune interactions †¢ †¦ways in which the immune system can be advantageously manipulated to protect against or treat disease What is Immunity? †¢ Latin word â€Å"immunitas†, freedom from †¢ It refers to all mechanisms used by the body as protection against environmental agents that are foreign to the body. †¢ Can be either natural (innate or inborn) or acquired (adaptive) Function of the Immune System †¢ Recognize â€Å"self† from â€Å"nonself† †¢ Defend the body against nonself Physiologic function is to prevent infection and to eradicate established infections (sterilizing immunity) Key Characteristics of the Immune System †¢ Innate immunit y †¢ Primary response †¢ Secondary response and immunologic memory †¢ Immune response is highly specific †¢ Immune system is tolerant of self-antigens †¢ Immune responses against self-antigens can result in autoimmune diseases †¢ Immune responses against infectious agents do not always lead to elimination of the pathogen (HIV/AIDS) Major Principles of Immunity (immune response): Elimination of many microbial agents through the nonspecific protective mechanisms of the innate immune system. †¢ Cues from the innate immune system inform the cells of the adaptive immune system as to whether it is appropriate to make a response and what type of response to make. Major Principles of Immunity (immune response): †¢ Cells of the adaptive immune system display exquisitely specific recognition of foreign antigens and mobilize potent mechanisms for elimination of microbes bearing such antigens. The immune system displays memory of its previous responses. à ¢â‚¬ ¢ Tolerance of self-antigens. Cells of the Immune System †¢ Lymphocytes – occupy the central stage; determines the specificity of immunity †¢ Dendritic cells (DCs) & Langerhan cells †¢ Monocyte/macrophages †¢ Natural killer (NK) cells †¢ Neutrophils †¢ Mast cells & Basophils †¢ Eosinophils †¢ Epithelial and stromal cells – provides anatomic environment (secretion of critical factors that regulate migration, growth and homeostasis) Lymphoid Tissues and Organs Primary Lymphoid Organs Sites where pre-B and pre-T lymphocytes mature into naive T and B cells in the absence of foreign antigen; †¢ Fetal Liver, Adult bone marrow, and thymus The INNATE IMMUNE SYTEM INNATE IMMUNE SYSTEM †¢ relies on germ line-encoded receptors to detect a limited set of microbial structures that are uniquely associated with microbial infection †¢ not a function of a single defined physiologic system; rather, it is a product of multiple a nd diverse defense mechanisms Modules of the Innate Immune System †¢ Surface epithelium The phagocyte system – critical for the defense against both intracellular and extracellular bacteria as well as fungal pathogens; aided by opsonins †¢ Acute phase response and complement – variety of secreted proteins that function in the circulation and in tissue fluids; secreted by the hepatocytes in response to the inflammatory cytokines IL1 and IL-6 Modules of the Innate Immune System †¢ Natural killer (NK) cells are specialized in the elimination of infected host cells and in aiding defense against viral and other intracellular infections through production of cytokines(IFN-? ; regulated by type I interferons (IFN-? /? ) †¢ Mast cells, eosinophils, and basophils are specialized in defense against multicellular parasites, such as helminthes; regulated by several cytokines, including IL-4, IL-5, IL-9, and IL-13 Strategies of Innate Immune Recognition 1. Recog nition of microbial nonself – referred to as pattern recognition, based on the recognition of molecular structures that are unique to microorganisms and not produced by the host 2.Recognition of missing self – based on the recognition of molecules expressed only on normal, uninfected cells of the host Targets of Innate Immune Recognition †¢ PAMPs (pathogen-associated molecular patterns) – molecular structures produced by microbial pathogens, but not by the host organism †¢ PRRs (pattern recognition receptors) – receptors of the innate immune system and represents targets of the innate immune system Targets of Innate Immune Recognition Examples of PAMPs include: (1) LPS of gram-negative bacteria (2) LTA of gram-positive bacteria (3) Peptidoglycans (4) Lipoproteins of bacteria (cell wall) (5) Lipoarabinomannan of mycobacteria (6) dsRNA produced by virus during the infection cycle (7) ? -glucans and mannans found in fungal cell wall Receptors of th e Innate Immune System †¢ Broad categories of PRRs: (1) PRRs that signal the presence of infection; expressed on the cell surface or intracellularly Categories of gene products: a. proteins and peptides that have direct antimicrobial effector functions (antimicrobial peptides and lysozyme) b. nflammatory cytokines and chemokines (TNF, IL-1, IL-8) c. gene products that control activation of the adaptive immune response (MHC, CD80/CD86, IL-12) Receptors of the Innate Immune System †¢ Broad categories of PRRs: (2) Phagocytic (or endocytic) PRRs; expressed on the surface of macrophages, neutrophils, and dendritic cells(DCs) (3) Secreted PRRs (mannan-binding lectin and peptidoglycan-recognition proteins Function: a. activate complement b. opsonize microbials cells to facilitate their phagocytosis c. ccessory proteins for PAMP recognition by transmembrane receptors (TLR) Receptors of the Innate Immune System †¢ Toll-like Receptors – comprise a family of type 1 transm embrane receptors characterized by leucine rich repeats (LRRs) in the extracellular portion and an intracellular TIR (Toll/IL-1 receptor) domain; grouped into two classes: (1) TLRs 1, 2, 4, 5, and 6 are expressed on the plasma membrane and detect bacterial and fungal cell wall components; (2) TLRs 3, 7, and 9 are expressed in endosomal compartments and recognize viral nucleic acidsToll-like receptor 4 (TLR4) †¢ expressed predominantly in the cells of the immune system, including macrophages, DC, neutrophils, mast cells, and B cells †¢ also expressed on endothelial cells, fibroblasts, surface epithelial cells, and muscle cell †¢ Signal transducing receptor for LPS, heat sensitive protein associated with the cell walls of MTB †¢ Together with CD14 shown to mediate responsiveness to the fusion (F) protein of RSVToll-like receptor 2 (TLR2) †¢ Involved in recognition of LTA and peptidoglycan from gram-positive bacteria, bacterial lipoproteins, mycoplasma lipoprot ein, mycobacterial lipoarabinomannan, a phenol-soluble modulin from S. epidermidis, zymosan of yeast cell walls, and lipoglycosylphosphotidylinositol T. cruzi †¢ Also shown to recognize two kinds of atypical LPS: L. interrogans and Porphyromonas gingivitis Toll-like receptor 3 (TLR3) Receptor for dsRNA †¢ Can mediate responses to poly(IC) †¢ Expressed on DCs, macrophages, and surface epithelial cells, including instestinal epithelium †¢ Also expressed in CD8+ DCs Toll-like receptor 7 (TLR7) †¢ Involved in viral recognition and both detect nucleic acids together with TLR9 †¢ Recognizes viral ssRNA (derived from RNA viruses); TLR9 (unmethylated DNA derived from DNA viruses) †¢ Expressed primarily on plasmacytoid dendritic cells †¢ Activated by small antiviral compunds, e. g. imiquinoid †¢TLR7-mediated recognition takes place inside the late lysosomes Toll-like receptor 9 (TLR9) †¢ Involved in the antiviral host defense; especially on r ecognition of DNA viruses (HSV) †¢ Expressed in type-I INF-producing plasmacytoid DCs Phagocytic Receptors †¢ Scavenger receptors – cell-surface glycoproteins that are defined by their ability to bind to modified LDL †¢ Macrophage Mannose Receptor (MR) – type I transmembrane protein expressed primarily in macrophages; involved in phagocytosis of bacterial (MTB, P. eruginosa, K. pneumonia), fungal (S. cerevisae, C. albicans), and protozoan pathogens (P. carinii) Cells of the Innate Immune System †¢ Macrophages – most central and essential functions and have multiple roles in host defense (e. i. â€Å"housekeeping functions†); in red pulp of the spleen, it phagocytose and remove from circulation senescent RBCs †¢ Neutrophils †¢ Mast Cells – best known effectors of allergic response; protective role is by rapid production of TNF-? nd leukotriene B4 (neutrophil recruitement) Cells of the Innate Immune System †¢ Eosino phils – found primarily in the respiratory, intestinal, and genitourinary tracts; contains cationic effector proteins toxic to parasitic worms; poor phagocytes †¢ Dendritic Cells – immature DCs reside in peripheral tissues and are highly active in macropinocytosis and receptor-mediated endocytosis; expresses PRRs and TLRs; have roles in the initiation of adaptive immune response Cells of the Innate Immune System Suface Epithelium – lines the mucosal surfaces of the intestinal, respiratory, and genitourinary tracts provide an important physical barrier The Effector Mechanisms of the Innate Immune System The Major Categories of Antimicrobial Effector Enzymes that hydrolyze components of microbial cell walls Antimicrobial proteins and petides that disrupt the integrity of microbial cell walls †¢ Lysozyme †¢ Chitinases †¢ Phospholipase A2 †¢ †¢ †¢ †¢ †¢ BPI Defensins Cathelicidins Complement Eosinophil cationic protein Mi crobicidal serine proteasesProteins that sequester iron and zinc Enzymes that generate toxic oxygen and nitrogen derivatives †¢ Seprocidins †¢ Lactoferrin †¢ NRAMP †¢ calprotein †¢ Phagocytic oxidase †¢ Nitric oxide synthase †¢ myeloperoxidase The Effector Mechanisms of the Innate Immune System †¢ Lysozyme – a. k. a. muramidase; degrades the peptidoglycan of some gram(+) bacteria; highly concentrated in secretions such as tears and saliva †¢ Chitinases – enzymes that degrade chitin; secreted by activated macrophages and presumably play a role in antifungal defenseThe Effector Mechanisms of the Innate Immune System †¢ Defensins – cationic peptides with a broad spectrum of antimicrobial activities against gram(+) and gram(-) bacteria, fungi, parasites, and some envelope viruses; kill microorganisms by forming pores in the membranes; divided into ? – and ? defensins †¢ ? -defensins – presynthesize d and stored in granules of neutrophils and Paneth cells of the small intestine †¢ ? -defensins – produced by epithelial cells and not stored in cytoplasmic granulesThe Effector Mechanisms of the Innate Immune System †¢ Cathelicidins – active against gram(+) and gram(-) bacteria and fungi; produced in neutrophils and stored as inactive proproteins in the secondary granules †¢ Serprocedins – comprise a family of cationic serine proteases with antimicrobial activity (neutrophil elastase, proteinase 3, cathepsin G, and azurocidin); exert its antimicrobial activity by either perturbation of microbial membranes or by proteolysisThe Effector Mechanisms of the Innate Immune System †¢ Lactoferrin, NRAMP, and Calprotectin – antimicrobial activities are due to the ability to sequester iron and zinc †¢ Lactoferrin – found in the secondary granules of neutrophils, in epithelial secretions (e. i. breast milk), in the intestinal epitheli um of infants, and in airway fluids; bacteriostatic (iron sequestration) and bacteriocidal (perturbation of microbial membranes) The Effector Mechanisms of the Innate Immune System NRAMP (natural resistance-associated macrophage protein) – integral membrane protein that functions as an ion pump in the phagocytic vacuoles of macrophage and neutrophils †¢ Calprotectin – member of the family of calciumbinding proteins; microbial activity is by chelation and sequestration of zinc ion ACUTE PHASE REACTANTS †¢ Soluble factors which are normal constituents that increase or decrease rapidly as produ †¢ Not a function of a single defined physiologic system; rather, it is a product of multiple and diverse defense mechanisms

Free Essays on Melatonin

MELATONIN Melatonin is a hormone made by the pineal gland, located within your brain. Every day, as it gets later, the pineal gland goes to work by releasing increasing amounts of melatonin into your bloodstream. This hormone may play a role in many body processes. Your blood vessels, ovaries, gastrointestinal system and brain all have cells that are specially equipped to utilize melatonin. The main influence it has involves sleep. The time period in which the pineal gland releases the hormones coincides with the hours you typically sleep. It doesn’t cause you to fall asleep, but it initiates changes throughout your body that make you feel ready for sleep. Several studies have shown that 1 to 2 milligrams a day may help improve the quality and duration of sleep in some people. However, it appears melatonin supplements may help only the small number of insomniacs who have a melatonin deficiency. Much remains unknown about this hormone and its effects on your body, particularly when it’s used long-term or with other medications. There also concerns about the quality and purity of the supplements. Because it is not a drug, the FDA doesn’t regulate its safety. No serious side effects have yet been attributed to taking melatonin supplements, but doctors and scientist believe it may cause hypothermia, reduced fertility, suppression of male sex drive, and damage to the retina of the eye.... Free Essays on Melatonin Free Essays on Melatonin MELATONIN Melatonin is a hormone made by the pineal gland, located within your brain. Every day, as it gets later, the pineal gland goes to work by releasing increasing amounts of melatonin into your bloodstream. This hormone may play a role in many body processes. Your blood vessels, ovaries, gastrointestinal system and brain all have cells that are specially equipped to utilize melatonin. The main influence it has involves sleep. The time period in which the pineal gland releases the hormones coincides with the hours you typically sleep. It doesn’t cause you to fall asleep, but it initiates changes throughout your body that make you feel ready for sleep. Several studies have shown that 1 to 2 milligrams a day may help improve the quality and duration of sleep in some people. However, it appears melatonin supplements may help only the small number of insomniacs who have a melatonin deficiency. Much remains unknown about this hormone and its effects on your body, particularly when it’s used long-term or with other medications. There also concerns about the quality and purity of the supplements. Because it is not a drug, the FDA doesn’t regulate its safety. No serious side effects have yet been attributed to taking melatonin supplements, but doctors and scientist believe it may cause hypothermia, reduced fertility, suppression of male sex drive, and damage to the retina of the eye....

25 Google Power Search Tips for Genealogists

25 Google Power Search Tips for Genealogists Google is the search engine of choice for most genealogists I know, due to its ability to return relevant search results for genealogy and surname queries and its huge index. Google is much more than just a tool for finding Web sites, however, and most people surfing for information on their ancestors barely scratch the surface of its full potential. If you know what you are doing, you can use Google to search within Web sites, locate photos of your ancestors, bring back dead sites, and track down missing relatives. Learn how to Google as youve never Googled before. Begin With the Basics 1. All Terms Count - Google automatically assumes an implied AND between each of your search terms. In other words, a basic search will only return pages that include all of your search terms. 2. Use Lower Case - Google is case insensitive, with the exception of the search operators AND and OR. All other search terms will return the same results, regardless of the combination of upper and lower case letters used in your search query. Google also ignores most common punctuation such as commas and periods. Thus a search for Archibald Powell Bristol, England will return the same results as archibald powell bristol england. 3. Search Order Matters - Google will return results that contain all of your search terms, but will give higher priority to the earlier terms in your query. Thus, a search for power wisconsin cemetery will return pages in a different ranked order than wisconsin power cemetery. Put your most important term first, and group your search terms in a way that makes sense. Search With a Focus 4. Search for a Phrase - Use quotation marks around any two word or greater phrase to find results where the words appear together exactly as you have entered them. This is especially useful when searching for proper names (i.e. a search for thomas jefferson will bring up pages with thomas smith and bill jefferson, while searching for thomas jefferson will only bring up pages with the name thomas jefferson included as a phrase. 5. Exclude Unwanted Results - Use a minus sign (-) before words that you want to be excluded from the search. This is especially useful when searching for a surname with a common usage such as rice or one which is shared with a famous celebrity such as Harrison Ford. Search for ford -harrison to exclude results with the word harrison. It also works well for cities that exist in more than one area such as shealy lexington south carolina OR sc -massachusetts -kentucky -virginia. You have to be careful when eliminating terms (especially place names), however, because this will exclude pages that have results including both your preferred location and the ones you eliminated. 6. Use OR to Combine Searches - Use the term OR between search terms to retrieve search results that match any one of a number of words. The default operation for Google is to return results that match ALL search terms, so by linking your terms with OR (note that you have to type OR in ALL CAPS) you can achieve a bit more flexibility (e.g. smith cemetery OR gravestone will return results for smith cemetery and smith gravestone). 7. Exactly What You Want - Google employs a number of algorithms to ensure accurate search results, including automatically considering searches for words that are common synonyms to be identical, or suggesting an alternate, more common spellings. A similar algorithm, called stemming, returns not only results with your keyword, but also with terms based on the keyword stem - such as powers, power and powered. Sometimes Google can be a little too helpful, however, and will return results for a synonym or word that you may not want. In these cases, use quotation marks around your search term to ensure that it is used exactly as you typed it (e.g. power surname genealogy) 8. Force Additional Synonyms - Although Google search automatically displays results for certain synonyms, the tilde symbol (~) will force Google to show additional synonyms (and related words) for your query. For example, a search for schellenberger ~vital records leads Google to return results including vital records, birth records, marriage records, and more. Similarly, ~obituaries will also include obits, death notices, newspaper obituaries, funeral, etc. Even a search for schellenberger ~genealogy will yield different search results than schellenberger genealogy. Search terms (including synonyms) are bolded in Google search results, so you can easily see what terms were found on each page. 9. Fill in the Blanks - Including an *, or wildcard, in your search query tells Google to treat the star as a placeholder for any unknown term(s) and then find the best matches. Use the wildcard (*) operator to end a question or phrase such as ​william crisp was born in * or as a proximity search to find terms located within two words of each other such as david * norton (good for middle names and initials). Note that the * operator works only on whole words, not parts of words. You cant, for example, search for owen* in Google to return results for Owen and Owens. 10. Use Googles Advanced Search Form - If the search options above are more than you want to know, try using Googles Advanced Search Form which simplifies most of the search options previously mentioned, such as using search phrases, as well as removing words you dont want included in your search results. Search Suggested Alternate Spellings Google has become one smart cookie and now suggests alternate spellings for search terms which appear to be misspelled. The search engines self-learning algorithm automatically detects misspellings and suggests corrections based on the most popular spelling of the word. You can get a basic idea of how it works by typing in geneology as a search term. While Google will return search results for pages on geneology, it will also ask you Did you mean genealogy? Click on the suggested alternate spelling for a whole new list of sites to browse! This feature comes in particularly handy when searching for cities and towns for which you arent sure of the correct spelling. Type in Bremehaven and Google will ask you if you meant Bremerhaven. Or type in Napels Italy, and Google will ask you if you meant Naples Italy. Watch out, however! Sometimes Google chooses to display the search results for the alternate spelling and youll need to select the correct spelling to find what you are really looki ng for. Bring Back Sites From the Dead How many times have you found what looks to be a very promising Web site, only to get a File Not Found error when clicking on the link? Genealogical Web sites seem to come and go every day as webmasters change file names, switch ISPs, or just decide to remove the site because they can no longer afford to maintain it. This doesnt mean the information is always gone forever, however. Hit the Back button and look for a link to a cached copy at the end of the Google description and page URL. Clicking on the cached link should bring up a copy of the page as it appeared at the time that Google indexed that page, with your search terms highlighted in yellow. You can also return Googles cached copy of a page, by preceding the pages URL with cache:. If you follow the URL with a space separated list of search words, they will be highlighted on the returned page. For example:  cache:genealogy.about.com surname  will return the cached version of this sites homepage with the term surname high lighted in yellow. Find Related Sites Found a site that you really like and want more? GoogleScout can help you find sites with similar content. Hit the Back button to return to your Google search results page and then click on the  Similar Pages  link. This will take you to a new page of search results with links to pages which contain similar content. The more specialized pages (such as a page for a specific surname) may not turn up many relevant results, but if you are researching a particular topic (i.e. adoption or immigration), GoogleScout can help you find a large number of resources very quickly, without having to worry about selecting the right keywords. You can also access this feature directly by using the related command with the URL of the site that you like (  related:genealogy.about.com). Follow the Trail Once youve found a valuable site, chances are that some of the sites which link to it may also be beneficial to you. Use the  link  command along with a URL to find pages which contain links pointing to that URL. Enter  link:familysearch.org  and youll find about 3,340 pages which link to the homepage of familysearch.org. You can also use this technique to find out who, if anyone, has linked to your personal genealogy site. Search Within a Site While many major sites have search boxes, this isnt always true of smaller, personal genealogy sites. Google comes to the rescue again, however, by allowing you to restrict search results to a specific site. Just enter your search term followed by the  site  command and the main URL for the site you wish to search in the Google search box on the main Google page. For example,  military site:www.familytreemagazine.com  pulls up 1600 pages with the search term  military  on the Family Tree Magazine Web site. This trick is especially useful for quickly finding surname information on genealogy sites without indexes or search capabilities. Cover Your Bases When you really want to make sure you havent missed a good genealogy site, enter  allinurl:genealogy  to return a list of sites with  genealogy  as part of their URL (can you believe that Google found more than 10 million?). As you can tell from this example, this is a better option to use for more focused searches, such as surnames or locality searches. You can combine multiple search terms, or use other operators such as OR to help focus your search (i.e.  allinurl:genealogy france  OR  french). A similar command is also available to search for terms contained within a title (i.e.  allintitle:genealogy france  OR  french). Find People, Maps and More If youre searching for U.S. information, Google can do so much more than just search Web pages. The lookup information they provide through their search box has been expanded to include street maps, street addresses, and phone numbers. Enter a first and last name, city, and state to find a phone number. You can also do a reverse lookup by entering a phone number to find a street address. To use Google to find street maps, just enter a street address, city, and state (i.e.  8601 Adelphi Road College Park MD), in the Google search box. You can also find business listings by entering the name of a business and its location or zip code (i.e.  tgn.com utah). Pictures From the Past Googles image search feature makes it easy to locate photos on the Web. Just click on the Images tab on Googles home page and type in a keyword or two to view a results page full of image thumbnails. To find photos of specific people try putting their first and last names within quotes (i.e.  laura ingalls wilder). If youve got a bit more time or a more unusual surname, then just entering the surname should be enough. This feature is also a great way to find photos of old buildings, tombstones, and even your ancestors hometown. Because Google doesnt crawl for images as often as it does for Web pages, you may find many pages/images have moved. If the page doesnt come up when you click on the thumbnail, then you may be able to find it by copying the URL from below the feature, pasting it into the Google search box, and using the cache feature. Glancing Through Google Groups If youve got a bit of time on your hands, then check out the Google Groups search tab available from the Google homepage. Find info on your surname, or learn from the questions of others by searching through an archive of over 700 million Usenet newsgroup messages going back as far as 1981. If youve got even more time on your hands, then check out this  historical Usenet timeline  for a fascinating diversion. Narrow Your Search by File Type Typically when you search the Web for information, you expect to pull up traditional Web pages in the form of HTML files. Google offers results in a variety of different formats, however, including .PDF (Adobe Portable Document Format), .DOC (Microsoft Word), .PS (Adobe Postscript), and .XLS (Microsoft Excel). These files appear among your regular search results listings where you can either view them in their original format, or use the  View as HTML  link (good for when you dont have the application that is needed for that particular file type, or for when computer viruses are a concern). You can also use the filetype command to narrow your search to find documents in particular formats (i.e. filetype:xls genealogy forms). You arent likely to use this Google feature often, but I have used it to find genealogy brochures in PDF format and family group sheets and other genealogy forms in Microsoft Excel format. If youre someone like me who uses Google quite a bit, then you may want to consider downloading and using the Google Toolbar (requires Internet Explorer Version 5 or later and Microsoft Windows 95 or later). When the Google Toolbar is installed, it automatically appears along with the Internet Explorer toolbar and makes it easy to use Google to search from any Web site location, without returning to the Google home page to begin another search. A variety of buttons and a drop-down menu make it easy to perform all of the searches described in this article with just a click or two. Best wishes for a successful search!

Fathers and Their Families Essay Example | Topics and Well Written Essays - 500 words - 24

Fathers and Their Families - Essay Example When fathers are not at home, the economic welfare of the family is adversely affected because mothers bear all the family financial burdens.a) When fathers are not at home, the economic welfare of the family is adversely affected because mothers bear all the family financial burdens.b) Fathers are usually a sense of security to their families, thus their absence exposes the family to potential risks of abuse among others.c) Fathers’ absence from the family breaks down the smallest unit of a family thus jeopardizes its functioning.Now that I have looked at the overall family welfare when fathers are away from home, I will proceed to discuss what happens to children when their fathers are not at home.II. Fathers’ absence from the family negatively affects the development and welfare of children) Children from families with more concerned and caring fathers encounter fewer behavioral challenges than their counterparts from fatherless families (Howard et al., 2006).b) Girl child usually needs the father for proper psychological development and absence of the father from home for a few hours or permanently servers the connection girls have with their fathers.c) Children are more likely to engage in early drug and substance abuse when their fathers are not at home. In conclusion, today, I have covered what happens to the family when fathers are away at home, which includes weakened social and economic strength as well as disturbed child development. When fathers are away from home, either for a short duration or permanently, their families are often adversely affected.  

The Proctor & Gamble Company Executive Financial Summary Research Paper

The Proctor & Gamble Company Executive Financial Summary - Research Paper Example The net sales for P&G remained at $79,029 million in the year 2009 whereas its net sales in 2008 were a bit high amounting to $81,748 million. The net sales for the year 2007 remained at $74,832 million. The net income for P&G remained at $13,436 million in the year 2009 whereas its net income in 2008 remained a bit low amounting to $12,075 million. For the year 2007, the net income for the year remained at $10,340 million. Cash generated by Operating Activities for P&G remained at $14,919 million in the year 2009 whereas its Cash generated by Operating Activities in 2008 remained a bit high amounting to $15,008 million. For the year 2007, Cash generated by Operating Activities for the year remained at $13,410 million. Cash used in Investing Activities for P&G remained at $(2,353) million in the year 2009 whereas its Cash used in Investing Activities in 2008 remained a bit high amounting to $(2,549) million. For the year 2007, Cash used in Investing Activities for the year remained at $(2,483) million. Cash generated by Financing Activities for P&G remained at $(10,814) million in the year 2009 whereas its Cash generated by Financing Activities in 2008 remained a bit high amounting to $(14,844) million. For the year 2007, Cash generated by Financing Activities for the year remained at $(12,453) million. P&G - A Company History - 1837-Today. (2012). P&G - A Company History - 1837-Today. Retrieved October 14, 2012, from P&G - A Company History - 1837-Today: